Topics related to the INTERVALS platform:

Tutorials
Publish your data
Editorial_board
FAQ button

 

Beyond INTERVALS - tools, platforms, and resources of interest:

Research_tools
sbv_IMPROVER
Articles
Videos

Tutorials

Share your data

Editorial board

Publication of scientific content on INTERVALS will be overseen by an Editorial Board (“EB”) consisting of experts in the areas of public health, toxicology, and systems biology, as well as statisticians, open science advocates, online database managers, and, of course, researchers studying the safety of consumer products, including tobacco and nicotine-containing products.

We are currently looking for editorial board members. More detail on the composition of the board and its function will be shared once the board is officially instated.

FAQ

 

  • Where can I find a definition for terms used in this site?

    You can find definitions of specific terms on the website Glossary

  • Who is developing and funding INTERVALS?

    Philip Morris International R&D initiated the creation of INTERVALS with the intention to build an online platform enabling independent, third-party collaboration and data analysis by sharing protocols, tools, and data from assessment studies proactively. Data files are accompanied by the relevant information to foster reproducible research and by high-level summaries of obtained results. As the platform also hosts protocols and results from in vivo inhalation studies and in vitro studies describing the chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol from this and other candidate and potential modified risk tobacco products, it can serve as an invaluable source of scientific assessment data. 
    The site and associated data warehouse are developed in collaboration with Emakina and Edelweiss Connect GmbH.

  • What is the current scope of INTERVALS?

    The INTERVALS platform and its associated data warehouse were created as a sharing platform for all studies, protocols, and data related to risk assessment of potential and candidate modified risk tobacco products as well as for reporting mechanistic investigations linked to tobacco-related diseases and pathways of toxicity.

  • How can I contribute?

    Strengthened by community features, INTERVALS aims to enable the necessary dialogue between industry, independent reviewers, the public health community, the research community, and regulatory agencies that can validate the harm reduction potential of potential and candidate modified risk tobacco products.

    Any institution producing relevant data on potential modified risk tobacco products (from aerosol characterization to molecular data) is invited to contribute to this infrastructure to facilitate scientific exchange and data reusability in the context of tobacco harm reduction.

    The dedicated protocols page should also allow to share and improve methods used in 21st Century Toxicology as well as mechanistic investigation of key biological processes and diseases.

Research tools

  • Links

    What can I do with it?

  • sbv IMPROVER is a crowdsourcing initiative that aims to encourage innovation and evaluation of scientific methods in an industrial setting. By 2020, more than 850 experts from more than 500 institutions based in 65 countries had been part of the 11 sbv IMPROVER challenges and datathons. This resulted in 16 scientific publications and more than 20 collaborations between experts, institutions, and PMI.

  • The Causal Biological Networks (CBN) database is composed of multiple versions of over 120 modular, manually curated, BEL-scripted biological network models describing lung and cardiovascular biology and supported by over 80,000 unique pieces of evidence from the scientific literature.

  • AeroSolved is a Computational Fluid Dynamics code, based on the OpenFOAM software package, for simulation of the generation, transport, evolution, and deposition of multispecies aerosol mixtures. The AeroSolved website includes tutorial cases, documentation, and links to the code hosted on GitHub.

  • Garuda is an open, community-driven, common platform that provides a framework to connect, discover and navigate through different applications, databases and services in biology and medicine. Garuda provides language independent API to connect software as gadgets, explore them through the gateway and operate them through the dashboard, all the while supported by a global alliance of leaders in computational biology and informatics.

  • Nebion curates and integrates the world's expression data. Nebion provides high-quality curation, powerful search engine, and user-friendly data mining tools answering unique types of queries. Besides licensing curated content and analysis tools, Nebion offer services for the curation of public or private data, data analysis services and bioinformatics consulting.

  • The ABOUT™ Toolbox is a portfolio of self-report instruments meant to assess people’s perceptions, attitudes, and behaviours towards Reduced-Risk Products* in a scientific, robust manner.

sbv IMPROVER

sbv IMPROVER is a crowdsourcing initiative that aims to encourage innovation and evaluation of scientific methods in an industrial setting.

By 2020, more than 850 experts from more than 500 institutions based in 65 countries had been part of the 11 sbv IMPROVER challenges and datathons. This resulted in 16 scientific publications and more than 20 collaborations between experts, institutions, and PMI.

To learn more, visit the sbv IMPROVER pages.

Library: white papers and scientific handouts

Articles and white papers of general interest can be found in this section. Media and articles specific to studies can be found in the respective study pages.

Videos